Chlorogenic Acid Ameliorates Liver Function in Association with Bax Downregulation, P53 Downregulation and Bcl-2 Upregulation in Diabetic Wistar Rat

Hyperglycemia in Diabetes mellitus (DM) induces oxidative stress and mitochondrial disruptions the liver, thereby triggering apoptosis through Bcl-2 family signaling. Excessive leads to liver dysfunction. Chlorogenic acid (CGA) was elucidated this study preventing dysfunction as a progression of DM. The diabetic model conducted Wistar rats, divided into six groups. Blood examinations were done measure levels blood glucose, SGOT, SGPT. harvested for analysis SOD2, Bax, mRNA. A paraffin section used p53 immunostaining. Liver occurred DM 2 months group indicated by higher SGPT expression lower compared control group. Giving CGA 12.5 mg/kgBW ameliorated glucose enzyme levels, which associated with signaling p53, Administration did not affect SOD2 rats. may attenuate rats downregulation Bax upregulation